Aloe gel significantly improves wrinkles and elasticity in photoaged human skin.
Abstract: from GreenMedInfo
BACKGROUND: No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin.
OBJECTIVE: We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin.
METHODS: Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR.
RESULTS: After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups.
CONCLUSION: Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Substances : Aloe Vera : CK(725) : AC(189)
Diseases : Aging Skin : CK(677) : AC(168), Skin Diseases: Photo-Aging : CK(145) : AC(54), Wrinkles : CK(10) : AC(1)
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor : CK(99) : AC(59)
Abstract Title:
Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo.
Abstract Source:
Ann Dermatol. 2009 Feb;21(1):6-11. Epub 2009 Feb 28. PMID: 20548848
Abstract Author(s):
Soyun Cho, Serah Lee, Min-Jung Lee, Dong Hun Lee, Chong-Hyun Won, Sang Min Kim, Jin Ho Chung
Article Affiliation:
Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.
Aloe Vera Helps Prevent Systemic Disease Through Oral Health
Recent research has confirmed that poor oral health can result in diseases ranging from stroke and pancreatic cancer to obesity. Brushing alone is not always sufficient. A novel toothpaste provides targeted nutrients to help keep teeth and gums in optimal health.
Scientifically reviewed by Dr. Gary Gonzalez, MD, in May 2022. Written by: Michael Downey, Health & Wellness Author.
Aloe Vera
Long used to promote wound healing and soothe burns, topically applied aloe vera (Aloe barbadensis) has now been shown to promote wound healing and may provide soothing and healing properties to the gum tissues.9,61,62
Further, a 2015 study found that aloe vera inhibits tooth decay and periodontal pathogens.63
In a remarkable finding, a study published in the October 1, 2016, issue of the Journal of Clinical and Experimental Dentistry concluded that aloe vera “…can be used as an alternative product for curing and preventing gingivitis.”64 Full Article at Life Extension Magazine
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