Abstract: from GreenMedInfo
BACKGROUND: No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin.
OBJECTIVE: We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin.
METHODS: Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR.
RESULTS: After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups.
CONCLUSION: Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.
Article Published Date : Feb 01, 2009
Study Type : Human Study
Substances : Aloe Vera : CK(725) : AC(189)
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor : CK(99) : AC(59)
Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo.
Ann Dermatol. 2009 Feb;21(1):6-11. Epub 2009 Feb 28. PMID: 20548848
Soyun Cho, Serah Lee, Min-Jung Lee, Dong Hun Lee, Chong-Hyun Won, Sang Min Kim, Jin Ho Chung
Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.
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Long used to promote wound healing and soothe burns, topically applied aloe vera (Aloe barbadensis) has now been shown to promote wound healing and may provide soothing and healing properties to the gum tissues.9,61,62
Further, a 2015 study found that aloe vera inhibits tooth decay and periodontal pathogens.63
In a remarkable finding, a study published in the October 1, 2016, issue of the Journal of Clinical and Experimental Dentistry concluded that aloe vera “…can be used as an alternative product for curing and preventing gingivitis.”64 Full Article at Life Extension Magazine